CALL FOR PAPERS Metabolic Syndrome Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes
نویسندگان
چکیده
Fahim Abbasi, Sang-Ah Chang, James W. Chu, Theodore P. Ciaraldi, Cindy Lamendola, Tracey McLaughlin, Gerald M. Reaven, and Peter D. Reaven Department of Medicine, Stanford University School of Medicine, Stanford; Medical Research Service, Veterans Affairs San Diego Healthcare System and Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, California; and Medical Research Service, Division of Endocrinology and Metabolism, Department of Medicine, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona
منابع مشابه
Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes.
It has been suggested that changes in adiponectin levels may contribute to improved insulin sensitivity in insulin-resistant individuals both after weight loss and after treatment with thiazolidinedione compounds. If this is correct, then changes in total circulating adiponectin and/or distribution of its multimeric complexes should coincide with improvements in insulin sensitivity after both i...
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Background and objectives: The purpose of the present study was to examine the effect of a progressive resistance-training program beside an energy deficit diet on body Composition, insulin resistance and plasma adiponectin levels in overweight adult men. Methods: Twenty-five overweight men (age =32.1 ± 4.3 years, BMI =28.9 ± 1.3 kg.m-2) were randomly assigned into one of the two groups: resis...
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Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...
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Adiponectin circulates in human plasma mainly as a 180-kDa low molecular weight (LMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. We comprehensively examined the relationships between circulating levels of total adiponectin, adiponectin multimers, and the relative distribution (i.e., ratio) of multimeric forms with key features of the metabolic syndrome. Total a...
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Adiponectin is involved in the regulation of glucose and fatty acid metabolism, influences whole-body insulin sensitivity and protects arterial walls against the development of atherosclerosis. Plasma adiponectin is decreased in obese, insulin-resistant and Type 2 diabetic patients. Adiponectin circulates in plasma as high-, medium- and low-molecular-weight ('mass') forms (HMW, MMW and LMW resp...
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